On Fri, 25 Jul 2003 16:26:34 -0400
nikolay <niskrev@umich.edu> wrote:
> I apologies for asking a question not directly related to S.
> I wondered if there is a result (in medicine) that the optimal treatment is
> a non-linear function of the symptomes, e.g. no treatment prescribed for
> mild symptomes, but some treatment - for more severe symtomes. Can anyone
> recommend good reference - both theoretical and empirical on this topic.
> Thanks
>
For a start look at
@ARTICLE{cal97sel,
author = {Califf, Robert M. and Woodlief, Lynn H. and Harrell, Frank E. and
Lee, Kerry L. and White, Harvey D. and Guerci, Alan and Barbash,
Gabriel I. and Simes, {R. John} and Weaver, {W. Douglas} D. and
Simoons, Maarten L. and Topol, Eric J. and {The GUSTO-I
Investigators}},
year = 1997,
title = {Selection of thrombolytic therapy for individual patients:
{Development} of a clinical model},
journal = {American Heart Journal},
volume = 133,
pages = {630-639},
annote = {predicting treatment benefit for individual patients;use of
nonparametric smoothers in medical papers;absolute vs. relative
treatment effects}
}
---
Frank E Harrell Jr Prof. of Biostatistics & Statistics
Div. of Biostatistics & Epidem. Dept. of Health Evaluation Sciences
U. Virginia School of Medicine http://hesweb1.med.virginia.edu/biostat
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