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Re: random effects

To: Frank Lawrence <Cougar@psu.edu>
Subject: Re: random effects
From: Spencer Graves <spencer.graves@pdf.com>
Date: Mon, 29 Mar 2004 10:32:01 -0800
Cc: s-news@lists.biostat.wustl.edu
In-reply-to: <000001c415b3$89d78a30$641a7680@meth.hhdev.psu.edu>
References: <000001c415b3$89d78a30$641a7680@meth.hhdev.psu.edu>
User-agent: Mozilla/5.0 (Windows; U; Windows NT 5.0; en-US; rv:1.4) Gecko/20030624 Netscape/7.1 (ax)
Have you consulted Pinhiero and Bates (2000) Mixed-Effects Models in S and S-Plus (Springer)? On pp. 82-96, they discuss that very issue. In brief, they found from simulations that 2*log(likelihood ratio) in situations like this were well approximated by a mixtures of two chi-square distributions. My memory of that material is that one part is the naive chi-square that one would expect without the boundary constraint while other(s) has(have) reduced degrees of freedom. Pinhiero and Bates provide a insight into what occurs and why as well as a simulation methodology for evaluating the result in a particular context. I hope Doug or someone else will comment if I've missed or misunderstood something here. hope this helps. spencer graves

Frank Lawrence wrote:

When using lme to test if random effects are zero, I have used the anova
function to compare two models; one representing the null hypothesis the
other representing the alternative.  I would like to know if use of anova is
appropriate in these circumstances because I understand that the null
hypothesis places the parameter of interest on the boundary of the parameter
space.

Respectfully,

Frank R. Lawrence

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