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Re: How to fit a quadratic polynomial model using NLME?

To: "'Savitri Appana'" <saviappana@yahoo.com>, s-news@wubios.wustl.edu
Subject: Re: How to fit a quadratic polynomial model using NLME?
From: "Liaw, Andy" <andy_liaw@merck.com>
Date: Wed, 29 Sep 2004 20:47:07 -0400
What is the goal of the analysis?  If you want to draw formal inference
(e.g., reporting p-values), it's dangerous to `eyeball' a model from the
data, as that will most likely bias the p-values.

If all you want is a quadratic polynomial, that's not a nonlinear model, and
should be fitted with lm (or lme if you have random effects) with a poly()
term.

Andy

> From:  Savitri Appana
> 
> Hi everyone,
> 
> I need some help fitting a quadratic polynomial model
> with NLME.
> 
> I've seen that NLME has some of the common nonlinear
> models built-in, but I don't think I can use one of
> these models.  These built-in models are modeling
> curves with an apparent "asymptote" or more "S-shaped"
> or something more complicated than what I need.  The
> data I'm modeling has more of a quadratic look.
> 
> I'd greatly appreciate any comments or suggestions. 
> Thank you very much in advance.
> 
>  
> 
> Savi A.
> 
> Statistician
> 
> Jefferson Labs, FDA
> 
> Ph:  870-543-7623
> 
> E-mail:  saviappana@yahoo.com
> 
> 
> 
> 
> 
> 
>               
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