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Dr. Rice's current research interests include the collection and analysis of linkage and family data on the affective disorders, alcoholism and nicotine dependence as well as methodological development in genetic epidemiology. Dr. Rice is the PI of the St. Louis Center of the Collaborative Depression Study (CDS), a six-site follow-up study of depression, and PI on a linkage study using families from the CDS. He heads the data management portion of the Collaborative Study on the Genetics of Alcoholism (COGA), a six-site study to collect family and genetic linkage data. He is the PI for the NIMH Contract "Center for Genetic Studies" and a Co-PI for the NIDA Center. This latter contract is the one which supports the Center to which data from this Program Project will be contributed, so that Dr. Rice's role in both will facilitate the data-sharing aspects of this program. The system for data management of both phenotype and genotype data has evolved for over a decade. He has extensive experience with multisite collaborative studies and in previous large amounts of genetic data and preparing the necessary components for their analysis. Dr. Rice has a long history of methodologic contribution in the area of quantitative methods for genetic analysis. He is PI of a methodology grant to develop new methods. For the past few years he has worked with Dr. Pui Kwok of Washington University on the analysis of SNP data and the characterization of the exact linkage disequilibrium (LD) in various populations. A current theoretical intent is the development of methods to quantify LD for several markers (rather than simply pairwise methods), and to use this to construct an LD map.