The Family Blood Pressure Program Investigators, with support from the National Heart, Lung, and Blood Institute (NHLBI), have collected extensive clinical data and biological materials from the participants in the FBPP. This phenotypically and genetically well-characterized population represents a valuable scientific resource. Optimizing the informativeness and use of this resource on a scale commensurate with its importance will require a large and concerted effort. The FBPP investigators recognize their responsibility to the public in general, and to the scientific community in particular, to encourage rapid scientific progress by making these resources publicly available. Clinical Data and Biological Materials from individual Networks, as well as from the FBPP Pooled Data, are available to interested investigators.
The GenNet Network is a family-based study of blood pressure as a quantitative phenotype, recruiting probands with elevated blood pressure, along with their siblings and parents. It has collected and characterized data on 1,497 Caucasian-American subjects from Michigan as well as 1101 African-American and 839 Hispanic-American subject, from Illinois.
The GENOA Network (Genetic Epidemiology Network of Arteriopathy) is a family-based study of hypertension and diabetes, recruiting sibships with at least two hypertensive siblings. It has collected and characterized data on 1,606 Caucasian-American subjects, 1,857 African-American subjects, and 1,803 Hispanic-American subjects, from Minnesota, Mississippi, and Texas, respectively.
The HyperGEN Network (Hypertension Genetic Epidemiology Network) is a family-based study whose purpose is to examine the genetic causes of hypertension, recruiting hypertensive sibships, along with their normotensive adult offspring. In addition, it has a random sample of approximately 800 subjects. HyperGEN has collected data on 2,471 Caucasian-American subjects and 2,300 African-American subjects, from five field centers in Alabama, Massachusetts, Minnesota, North Carolina, and Utah.
The SAPPHIRe Network (Stanford Asian Pacific Program in Hypertension and Insulin Resistance) is a family-based study that aims to locate and characterize the genes that contribute to high blood pressure. It recruited hypertensive sibpairs and sibpairs discordant for hypertension, along with their siblings and parents. SAPPHIRe has collected data on 1,794 subjects from California and Taiwan with Chinese ancestry and 1,856 subjects from Hawaii with Japanese ancestry.
The Pooled Data consists of a subset of the most important phenotypic and genotypic variables from three of the four FBPP Networks. Phenotypic variables include blood pressure and hypertension status, anthropometry, medical history and family medical history, reproductive history, demographics, alcohol and smoking history, medication use and blood and urine laboratory results. Genotypic datasets include genome-wide microsatellite marker data, locus description/marker map file, extended family pedigrees (marker-based), allele frequency datasets, and some candidate gene/SNP data. Find out more.