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The SAPPHIRe Network |
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The SAPPHIRe Network (Stanford Asian Pacific Program in Hypertension and Insulin Resistance) has completed sampling of over 1,200 sibling pairs derived from more than 450 hypertensive families of Chinese and Japanese ancestry. Approximately 50% of the sibling pairs are concordant for hypertension, while 50% of the sibling pairs are discordant, consisting of one hypertensive and one hypotensive sibling. These investigators have completed a genome-wide scan using the Marshfield set of anonymous markers to test for linkage with hypertension and a number of intermediate phenotypes related to insulin resistance. Promising candidate genes are currently being explored in the Phase 1 population. Phase 2 of SAPPHIRe began in January 2001 with the re-examination of families of Japanese ancestry from Phase 1 and recruitment of a representative sample of 1000 individuals from a population of families of Japanese ethnicity. The SAPPHIRe Network's primary interests are the metabolic syndrome and the phenotypes, including hypertension, which are associated with it.
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