Core Course offerings - Clinical Track

First Summer Semester  

M21-505: Biostatistics for Research Workers
Department: Division of Biostatistics
Course Masters: Kenneth Schechtman and Chengjie Xiong
Credit Hours: 2 units
Frequency: Every summer (MTWThF 9:00 a.m.-12:00 p.m. in Summer 2009)
Description: Intensive summer course (July 19-30 in 2010) designed for those researchers who want to expand their knowledge of practical methods in statistics. Oriented toward statistical and epidemiological concepts, applications, practical hints and hands-on approach to data, rather than theory or derivation of formulas. Heavy use is made of SAS® for in-class examples and homework problems. We will cover classical methods (e.g., t-test, chi-square, correlation), multivariate methods (regression, logistic models, ANOVA, survival analysis), study design, probability, and maximum likelihood. Some selected topics are then covered in greater detail. Prerequisite: M21-503 Statistical Computing with SAS® or student must have practical experience with SAS® . Crosslisted as: M08-505A and L41-5066.

M21-515: Fundamentals of Genetic Epidemiology
Department: Division of Biostatistics
Course Masters: Treva Rice and YunJu Sung YunJu Sung
Credit Hours: 2 units
Frequency: Every summer (MTWThF 9:00 a.m.-12:00 p.m. in Summer 2009)
Description: Intensive two-week summer course conducted from August 2 - 13 in 2010. The course covers causes of phenotypic variation, familial resemblance and heritability (correlation, path analysis and variance components models), Hardy-Weinberg Equilibrium, major genes, ascertainment, study designs and basic concepts in linkage and association analysis.  Lab practice with various genetics programs (SEGPATH, PAP, SOLAR, MERLIN, QTDT) requires enrollment in M21-515A.

Participants are strongly encouraged to participate in the "Computing/Unix" and "Statistics" workshops offered free of charge prior to this course (July 1 - 7). For details, to register and to obtain the required the required permission of the Course Master contact the GEMS Program Manager (pa@wubios.wustl.edu or telephone 362-1052).

M21- 550: Introduction to Bioinformatics
Department: Division of Biostatistics
Course Masters: C. Charles Gu, Gary Stormo, and colleagues
Credit Hours: 2 units
Frequency: Every summer (MTWThF 9:00 a.m.- 12:00 p.m. in Summer 2009)
Description: Intensive two-week summer course offered August 16-27 in 2009. Designed to provide a broad exposure to the basic concepts, methodology and application of bioinformatics to solve biomedical problems. Specifically, the students will learn the basics of online genomic databases and database mining tools, and acquire understanding of mathematical algorithms in genome sequence analysis (alignment analysis, gene finding/predicting), gene expression microarray (genechip) analysis, and of the impact of recent developments such as protein microarrays or whole-genome DNA chips for genome-wide association studies. Prerequisite: M21-505 Biostatistics for Research Workers.

For details, to register and to receive the required permission of the Course Master contact the GEMS Program Manager ( pa@wubios.wustl.edu or telephone 362-1052).

Fall Semester

M21-5483 Human Linkage and Association Analysis
Course Masters: John Rice and colleagues
Credit Hours: 2 units
Frequency: Every Fall (TTh 9:30 - 11:00 a.m. in Fall 2009; starts Aug. 27, GEMS Suite, Shriners 3307)
Description: Basic Genetic concepts: meiosis, inheritance, Hardy-Weinberg Equilibrium, Linkage, segregation analysis; Linkage analysis: definition, crossing over, map functions, phase, LOD scores, penetrance, phenocopies, liability classes, multi-point analysis, non-parametric analysis (sibpairs and pedigrees), quantitative trait analysis, determination of power for mendelian and complex trait analysis; Linkage Disequilibrium analyses: allelic association (case control designs and family bases studies), whole genome association analysis; Quantitative Trait Analysis: measured genotypes and variance components. Prerequisite: M21-515 Fundamentals of Genetic Epidemiology. Cross-listed as L41-5483.

For details, to register and to receive the required permission of the Course Master contact the GEMS Program Manager (pa@wubios.wustl.edu or telephone 362-1052).

L41-5285: Fundamentals of Mammalian Genetics
Department: Department of Genetics
Course Masters: Michael Lovett and colleagues
Credit Hours: 3 units
Frequency: Every Fall (TTh 3:00 - 4:30 p.m., begins Tu, Sept.1 in Fall 2009, Biotech Bldg. 330)
Description: This course aims to provide both biologists and those with mathematical backgrounds with a basis in mammalian genetics. The course will include the following modules: Nucleic acid biochemistry; Gene and chromosome organization; Introduction to Human Genetics; Mutations and DNA repair; Cancer Genetics; Genomic methodologies; Biochemical genetics; Murine Genetics; Epigenetics; Neurodegenerative diseases; Mitochondrial disorders; Pharmacogenetics; Introduction to human population genetics; Applications of modern human genetics; Introduction to web-based informatics tools for molecular genetics. One of the required courses in the Quantitative Human Statistical Genetics graduate program and required of all GEMS M.S. Clinical Track candidates.

M17-528: Grantsmanship
Department: Clinical Investigation Program
Course Masters: Jay Piccirillo and Karen Dodson
Credit Hours: 3 units
Frequency: (Tu 4:00 - 6:00 p.m.in Fall 2009, beginning Sept. 4, in CRTC Classroom, 2nd floor Wohl Bldg.)
Students learn how to develop, write, critique and revise grants for submission. They also participate in mock study sessions.

Spring Semester  

U88-588: Epidemiology for Clinical Research
Department: Health Care Services, University College
Course Masters: Mario Schootman
Credit Hours: 3 units
Frequency: Every spring (Wed 4:30 - 7:00 p.m. in Spring 2010), 4444 Forest Park Building, room 6700
Description: The purpose of this course is to provide individuals an understanding of the use of epidemiological concepts and methods both in clinical research, in clinical issues, and in understanding medical literature concerning these issues. The course includes 1) discussion of theoretical concepts related to the application of epidemiology in clinical research, and 2) practical applications of the concepts covered.

For details, to register and to receive the required permission of the Course Master contact the GEMS Program Manager (pa@wubios.wustl.edu or telephone 362-1052).

Spring, Fall or Summer Semesters